The aim of this paper is to contribute to the understanding of the strengths and weaknesses of micro-simulation modelling generally and to residential mobility modelling specifically. Following methodological issues are discussed based on application of several experimental micro-simulation residential location choice models to the population of a middle-sized town catchment area in Czech Republic: micro-data availability, methods of data disaggregation, the multicollinearity of environmental factors and the reliability of highly stochastic models.